- Dendritic Myxofibrolipoma.
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Sung Nam Kim, Kye Hyun Kwon, Yeon Lim Suh
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Korean J Pathol. 2001;35(5):447-450.
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- Dendritic myxofibrolipoma is a recently described disease entity that represents a distinctive benign soft tissue neoplasm showing the combined features of spindle cell lipoma and the solitary fibrous tumor. Immunohistochemical stains reveal a strong positivity for vimentin, CD34 and bcl-2, which highlight the dendritic nature of the tumor cells by demonstrating slender complex cytoplasmic prolongations. There have been 12 cases of dendritic myxofibrolipomas reported in literature. In Korea, none of the cases have been described. We report such a case with a 28-year-old man who had a palpable subcutaneous mass on his right shoulder for 4 months. Grossly, the removed mass measured 11X7X5 cm and appeared to be a well-encapsulated, lipomatous tumor with marked myxoid appearance.
Microscopically, this tumor consisted of spindle cells admixed with dense collagen fibers and mature adipocytes in abundant myxoid stroma with high vascularity.
Immunohistochemically, the tumor cells were strongly reactive for vimentin and CD34 and weakly reactive for bcl-2, and negative for S-100 protein.
- A Study of Usefulness of Fine Needle Aspiration Cytology of the Thyroid Lesions.
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Kye Hyun Kwon, So Young Jin, Dong Wha Lee
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Korean J Cytopathol. 1996;7(2):111-121.
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- Fine needle aspiration cytology(FNAC) is preferred because of simplicity, safety, and reliability in the evaluation of patients with thyroid nodule or hyperplasia. However, there are a few limitations such as false-negative or false-positive cases and nondiagnostic material. To evaluate the usefulness of FNAC in thyroid lesions, we reviewed 704 FNAC cases of thyroid nodules from 1988 to 1994 at Soonchunhyang University Hospital.
The results are as follows.
1. Among 704 FNAC cases of thyroid gland, 571(81.1%) cases were benign, 12 (1.7%0) were suspicious, 71(10.1%0) were malignancy, and 50(7.1%)-were material insufficiency. The cytologic diagnoses of the benign lesions included 168 cases of follicular neoplasm, 139 cases of adenomatous goiter, 162 cases of follicular lesion such as follicular neoplasm or adenomatous goiter, 61 cases of Hashimoto's thyroiditis, 13 cases of subacute thyroiditis, and 28 cases of colloidal nodule or benign nodule. The malignant lesions included 68 cases of papillary carcinoma, two medullary carcinomas and a case of metastatic colon cancer.
2. The average number of cytologic smear slides was 4.12+/-1.81 in material insufficiency and 5.63+/-1.79 in diagnostic cases. This difference was statistically significant(p<0.00001).
3. Histological assessment of 150 cases revealed 2 false negative and 1 false positive cases. The false negative cases were a case of marked sclerosis in papillary carcinoma and an occult case of papillary, carcinoma. The false positive case resulted from pseudo-ground glass nuclei due to marked dry artifact.
4. Comparison between the FNAC and the histologic diagnosis revealed that INAC had a sensitivity of 93.5%, a specificity of 99.2%, a false negative rate of 64%, a false positive rate of 0.8%, and an overall diagnostic accuracy of 98.0%.
Therefore, FNAC of thyroid gland is a very reliable diagnostic method with excellent accuracy rate.
- Ovarian Mucinous Adenocarcinoma Associated with Mucinous Adenocarcinoma of the Uterine Cervix.
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Kye Hyun Kwon, Jeong Ja Kwak, So Young Jin, Dong Wha Lee
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Korean J Pathol. 1995;29(2):244-247.
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- When coexistence of carcinoma with similar histologic type is present in female genital tract, it is difficult to differentiate independent primary tumor from metastasis.
Most of them are endometrial and ovarian tumors, but coexistence of uterine cervical and ovarian tumor with similar histologic type is rare. We experienced an independent primary tumor of ovarian mucinous cystadenocarcinoma associated with mucinous adenocarcinoma of uterine cervix. The patient was a 50-year-old woman. She had a lower abdominal mass which was detected as a huge cyst on ultrasonography. Although the ovarian lesions were bilateral, features that preferred to consider independent primary tumor are listed as; absence of lymphatic or vascular invasion, absence of ovarian surface implant, superficial invasion of cervical tumor, absence of tumor in abdominal cavity, and disease free follow-up after removal of the tumor.
- Localized Pseudopolyposis of the Ascending Colon Associated with Granulomatous Colitis: A case report.
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Jeong Ja Kwak, Kye Hyun Kwon, So Young Jin, Dong Wha Lee
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Korean J Pathol. 1994;28(1):82-85.
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- Pseudopolyps represent discrete areas of mucosal inflammation and regeneration that are seen in a variety of inflammatory bowel disease including ulcerative colitis and Crohn's disease. These polyps are typically short, measuring less than 1.5 cm in height. Rarely, localized giant pseudopolyposis can occur, i.e., a collection of larger inflammatory pseudopolyps giving rise to a mass lesion within the colon. The most serious problem concerned with pseudopolyposis is a confusion with carcinoma. We experienced a case of localized giant pseudopolyposis causing partial large bowel obstruction. Right hemicolectomy was done for a preoperative diagnosis of ascending colon carcinoma. The resected specimen contained a circumferential lesion, which was composed of numerous interconnecting cylindrical villi, measuring 12 cm in length and 3 cm in height. Microscopically, these polypoid lesions were inflammatory pseudopolyps. Several deep fissure-like ulcerations were noted with multifocal microabscess, lymphoid hyperplasia and an area of noncaseating granuloma.
- Fine Needle Aspiration Cytology of Chondroblastoma Arising in the Rib: Report of A Case.
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Kye Hyun Kwon, So Young Jin, Dong Wha Lee
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Korean J Cytopathol. 1994;5(1):61-64.
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- Chondroblastoma is a benign bone tumor accounting for less than 1% of bone tumor. It infrequently involves the flat bones, among which ribs are particularly rare. On fine needle aspiration cytology, the diagnostic smear consists of chondroblasts, osteoclast-like giant cells, and chondroid matrix. The cytologic hallmark to differentiate from other giant cell-containing lesions is chondroblasts.
- Fine needle aspiration cytology of Ki-1 positive large cell lymphoma-a case report-.
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Kye Hyun Kwon, Jeong Ja Kwak, So Young Jin, Dong Wha Lee
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Korean J Cytopathol. 1993;4(2):127-132.
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- No abstract available.
- Electron microscopic study on fine needle aspiration cytology of metastatic malignant melanoma.
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Dong Wha Lee, So Young Jin, Kye Hyun Kwon
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Korean J Cytopathol. 1992;3(2):82-89.
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Abstract
- No abstract available.
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